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Related Experiment Videos

CSF creatinine in schizophrenia.

C G Swahn1, G Sedvall

  • 1Department of Psychiatry and Psychology, Karolinska Institutet, Stockholm, Sweden.

Biological Psychiatry
|March 15, 1988
PubMed
Summary
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Cerebrospinal fluid creatinine levels are lower in schizophrenia patients. Sulpiride treatment, but not chlorpromazine, increased creatinine concentrations in these patients.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Schizophrenia is a complex neurological disorder with debated biochemical underpinnings.
  • Cerebrospinal fluid (CSF) analysis offers insights into the central nervous system's biochemical environment.

Purpose of the Study:

  • To investigate creatinine concentrations in the CSF of schizophrenia patients compared to healthy controls.
  • To explore the relationship between CSF creatinine and neurotransmitter metabolites.
  • To assess the impact of antipsychotic medications on CSF creatinine levels.

Main Methods:

  • Liquid chromatography was employed to quantify creatinine concentrations in CSF samples.
  • CSF samples were collected from individuals diagnosed with schizophrenia and healthy control subjects.

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  • Correlations between creatinine levels and homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were analyzed.

    • Main Results:

    • CSF creatinine concentrations were significantly lower in schizophrenia patients (42.8 nmol/ml) compared to healthy controls (54.4 nmol/ml).
    • A correlation was observed between CSF creatinine levels and the concentrations of HVA and 5-HIAA.
    • Treatment with sulpiride (800 mg/day) led to an increase in CSF creatinine, whereas chlorpromazine did not.

    Conclusions:

    • Reduced CSF creatinine may be a biochemical marker associated with schizophrenia.
    • Creatinine levels in CSF show a relationship with key dopaminergic and serotonergic metabolites.
    • Sulpiride shows a potential to modulate CSF creatinine levels in schizophrenia patients, suggesting a possible mechanism of action.