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Aortic stiffness is associated with left ventricular diastolic dysfunction in systemic lupus erythematosus: a

Carlos A Roldan1, Ihab B Alomari, Khaled Awad

  • 1Department of Medicine, Divisions of Cardiology and Rheumatology, University of New Mexico School of Medicine, Albuquerque, New Mexico.

Clinical Cardiology
|February 12, 2014
PubMed

Insights

Aortic stiffness is linked to left ventricular diastolic dysfunction in systemic lupus erythematosus (SLE) patients. This study confirms this association, highlighting potential cardiovascular risks in SLE.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Echocardiography

Background:

  • Systemic lupus erythematosus (SLE) is frequently associated with cardiovascular complications.
  • Aortic stiffness and left ventricular (LV) diastolic dysfunction are common in SLE patients, contributing to increased morbidity and mortality.

Purpose of the Study:

  • To investigate the association between aortic stiffness and LV diastolic dysfunction in patients with SLE.
  • To determine if aortic stiffness is an independent predictor of LV diastolic dysfunction in this population.

Main Methods:

  • A 6-year cross-sectional study involving 76 SLE patients and 26 healthy controls.
  • Transesophageal echocardiography (TEE) was used to assess LV diastolic function and descending thoracic aorta stiffness via pressure-strain elastic modulus (PSEM).
  • Aortic strain, stiffness, and distensibility were also evaluated to validate PSEM findings.

Main Results:

  • SLE patients exhibited significantly higher aortic stiffness (PSEM) and impaired LV diastolic function compared to controls.
  • Aortic stiffness (PSEM) was independently correlated with multiple parameters of LV diastolic dysfunction in SLE patients.
  • Worse aortic strain, stiffness, and distensibility were observed in SLE patients and correlated with diastolic dysfunction markers.

Conclusions:

  • Aortic stiffness is independently associated with left ventricular diastolic dysfunction in young adult patients with SLE.
  • These findings underscore the importance of monitoring aortic health in SLE management to mitigate cardiovascular risk.
Abstract

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