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Published on: August 2, 2024
miR-335 represents an independent prognostic marker in epithelial ovarian cancer
1Dept of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan. Hubei Province, No. 1277, Jiefang Avenue, Wuhan 443000, China; zehuawang@163.net.
Objectives:
To investigate the clinical significance of miR-335 expression in epithelial ovarian cancer (EOC).
Methods:
Expression of miR-335 in normal ovaries, EOC, and omental metastases was determined by quantitative realtime polymerase chain reaction. Overall survival (OS) and relapse-free survival (RFS) were examined using KaplanMeier curves and the Cox proportional hazards regression model.
Results:
miR-335 expression level was reduced in malignant tissue samples, especially in omental metastases. Low miR-335 levels in EOC were associated with shorter OS (P < .001) and RFS (P = .002). In the multivariate analyses, low miR-335 levels emerged as an independent prognostic factor for poor OS (P = .005) and RFS (P = .016). miR-335 was downregulated in the recurrence group compared with the nonrecurrence group. The area under the receiver operating characteristic curve was 0.818 (95% confidence interval, 0.675-0.961).
Conclusions:
Our results indicate that miR-335 relates to the prognosis of patients with EOC and is a promising predictor of EOC recurrence.
