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Limitations of embryo selection methods.

Kai Mee Wong1, Sjoerd Repping1, Sebastiaan Mastenbroek1

  • 1Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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Summary
This summary is machine-generated.

Embryo selection in in vitro fertilization (IVF) may not improve live birth rates. Preserving all embryos and transferring them in subsequent cycles might maintain or improve pregnancy rates, potentially shortening time to pregnancy.

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • Genetics

Background:

  • Embryo selection in in vitro fertilization (IVF) traditionally relies on morphology, but success rates remain suboptimal.
  • Preimplantation genetic screening (PGS) has been explored but demonstrated limitations compared to morphological assessment.

Purpose of the Study:

  • To evaluate the evolving landscape of embryo selection methods in IVF.
  • To question the established paradigm that improved embryo selection directly correlates with better IVF outcomes.

Main Methods:

  • Review of current embryo selection techniques, including morphological assessment and preimplantation genetic screening (PGS).
  • Analysis of emerging non-invasive selection methods and cryopreservation strategies.

Main Results:

  • Accumulating evidence suggests cryopreserving all embryos for sequential transfer may maintain or improve pregnancy rates.
  • The benefit of embryo selection may be limited to optimizing the time to pregnancy by prioritizing embryos with the highest implantation potential.

Conclusions:

  • The necessity and efficacy of stringent embryo selection in IVF are being re-evaluated.
  • Cryopreservation of all embryos for subsequent transfers presents a viable alternative to improve IVF outcomes and reduce the live birth rate impact of selection.