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Updated: May 3, 2026
Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature
Published on: October 14, 2022
Association between a lumican promoter polymorphism and high myopia in the Chinese population: a meta-analysis of
Zhu-Jun Deng1, Ke-Qing Shi, Yi-Jiang Song
1School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, PR China.
Purpose:
To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations.
Methods:
An electronic search was conducted in Pubmed, Embase, Cochrane Library and the China Biological Medicine Database for articles published prior to September 30, 2012. A meta-analysis was performed to assess heterogeneity, combine results and determine publication bias.
Results:
This meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers (odds ratio: 0.531; 95% confidence interval, CI: 0.304-0.925; p = 0.025). There was some heterogeneity between studies. A metaregression showed that the mean axial length of controls weakens the effect of rs3759223 on high myopia (slope: -0.914; 95% CI: -1.490 to 0.337; p = 0.002). Sensitivity analysis confirmed the reliability and stability of this meta-analysis.
Conclusion:
Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia.
