Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of plasma prekallikrein and kallikrein inhibitors during intravenous phlebography.

H J Aronen1, I Torstila, E Vahtera

  • 1Department of Diagnostic Radiology, Helsinki University Central Hospital, Finland.

European Journal of Radiology
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Von Willebrand disease in Finland.

Haemophilia : the official journal of the World Federation of Hemophilia·2013
Same author

Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old.

Neurology·2010
Same author

Prothrombin activation fragment 1 + 2 as a marker of coagulation activation in cord blood collection for banking.

Transfusion medicine (Oxford, England)·2010
Same author

Systematically missing confounders in individual participant data meta-analysis of observational cohort studies.

Statistics in medicine·2009
Same author

The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old.

Neurology·2007
Same author

Diffusion and perfusion-weighted magnetic resonance imaging techniques in stroke recovery.

Europa medicophysica·2007

Intravenous contrast media can activate contact systems, potentially causing side effects. High-osmolality contrast agents significantly decreased plasma prekallikrein, indicating kallikrein-kinin system activation and intrinsic coagulation during phlebography.

Area of Science:

  • Biochemistry
  • Hematology
  • Radiology

Background:

  • Intravenous (IV) contrast media are widely used in medical imaging.
  • Adverse effects associated with IV contrast media are a significant clinical concern.
  • Complex contact activation systems are implicated in the side effects of contrast media.

Purpose of the Study:

  • To investigate the involvement of contact activation systems in the side effects of IV contrast media.
  • To compare the effects of high-osmolality and low-osmolality contrast media on coagulation factors.
  • To assess the activation of the kallikrein-kinin system and intrinsic coagulation post-phlebography.

Main Methods:

  • Quantitative measurements of plasma prekallikrein and other factors were performed before and after IV contrast phlebography.

Related Experiment Videos

  • Two groups of 21 patients each were studied, one receiving high-osmolality meglumine iodamide and the other low-osmolality ioxaglate.
  • Patients with no history of thrombosis were included in the study.

    • Main Results:

    • A statistically significant decrease in plasma prekallikrein was observed following the administration of high-osmolality contrast medium.
    • This decrease in plasma prekallikrein suggests activation of the kallikrein-kinin system.
    • The findings indicate potential activation of the intrinsic coagulation pathway.

    Conclusions:

    • High-osmolality contrast media can activate the kallikrein-kinin system during phlebography.
    • Activation of contact systems, particularly the kallikrein-kinin system, may contribute to adverse effects of contrast media.
    • Further research is warranted to elucidate the precise mechanisms linking contrast media, contact activation, and patient side effects.