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Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
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Morphogenesis at criticality.

Dmitry Krotov1, Julien O Dubuis, Thomas Gregor

  • 1Joseph Henry Laboratories of Physics, Lewis-Sigler Institute for Integrative Genomics, and Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544.

Proceedings of the National Academy of Sciences of the United States of America
|February 12, 2014
PubMed
Summary
This summary is machine-generated.

Fruit fly embryo development relies on gene networks. Analysis reveals these networks operate at criticality, exhibiting specific fluctuation patterns and long-range correlations, suggesting a finely tuned system for pattern formation.

Keywords:
Drosophila embryogenetic networks

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Area of Science:

  • Developmental biology
  • Systems biology
  • Genetics

Background:

  • Early fruit fly embryo development involves complex gene interactions.
  • Transcription factors, specifically gap genes, are crucial for establishing spatial patterns.
  • Maternal inputs initiate these genetic networks.

Purpose of the Study:

  • To investigate if the fruit fly gap gene network operates at criticality.
  • To identify and analyze signatures of criticality within the gene network.

Main Methods:

  • Analysis of experimental data from fruit fly embryos.
  • Examination of gene expression fluctuations and their correlations.
  • Comparison of observed phenomena with theoretical predictions of criticality.

Main Results:

  • Observed strong correlations in gene expression fluctuations.
  • Detected long-range correlations in expression patterns across the embryo.
  • Noted deviations from Gaussian distribution in expression fluctuations.
  • Confirmed that these signatures align with theoretical predictions for criticality.

Conclusions:

  • The fruit fly gap gene network exhibits multiple signatures of criticality.
  • The observed phenomena are consistent with the network being tuned to a critical state.
  • This criticality may be essential for robust pattern formation in early development.