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Chronic myeloid leukemia data from India.

Shweta Bansal¹, Kumar Prabhash², Purvish Parikh³

¹Department of Medical Oncology, Asian Institute of Oncology, Mumbai, Maharashtra, India.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology

|February 12, 2014

Summary

Indian Cooperative Oncology Network (ICON) data reveals chronic myeloid leukemia (CML) patients present younger, with higher resistance and poorer outcomes in late stages. However, survival and quality of life have improved, with generic drugs offering a viable option.

Keywords:

Chronic myeloid leukemia India Indian cooperative oncology network mylestone

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Area of Science:

Oncology
Hematology
Clinical Research

Background:

Chronic myeloid leukemia (CML) management in India.
Need for collaborative data analysis across diverse Indian settings.
ICON initiative to consolidate CML patient data.

Purpose of the Study:

To present a summarized overview of CML patient data from across India.
To analyze real-world outcomes of CML patients in routine clinical practice.
To identify trends in CML presentation, treatment resistance, and outcomes in India.

Main Methods:

Compilation and analysis of data from 8115 CML patients presented at an ICON meeting.
Inclusion of data from 18 centers, comprising 6677 patients in submitted manuscripts.
Review of clinical practice data reflecting day-to-day patient management.

Main Results:

CML patients in India present at a younger age.
Increased incidence of treatment resistance and poorer outcomes observed in late chronic phase CML.
Analysis of Glivec versus generic drug efficacy, Imatinib safety in pregnancy, and mutational analysis in resistant cases.

Conclusions:

Survival and quality of life for CML patients in India have improved, particularly with early-phase treatment.
Generic CML drugs are a cost-effective alternative when original medications are inaccessible.
The ICON data serves as a foundation for future systematic studies on CML treatment in India.