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Updated: May 3, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Short-term longitudinal study of central auditory function in Alzheimer's disease and mild cognitive impairment
Esma Idrizbegovic1, Christina Hederstierna1, Martin Dahlquist1
1Department of Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden.
Background/Aims:
Central auditory function can be studied to monitor the progression of mild cognitive impairment to dementia. Our aim was to address this issue in a prospective longitudinal setting.
Methods:
Tests of central hearing function were performed on 70 subjects with either Alzheimer's disease (AD) or mild cognitive impairment, and in controls with subjective memory complaints but normal cognition. The time span until follow-up was 1.5 years.
Results:
The dichotic digit free recall test showed a significant decline in the AD group compared with the controls (left ear).
Conclusion:
The short time span was long enough to disclose a central auditory processing decline in AD.
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