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The simple predictors of pseudomembranous colitis in patients with hospital-acquired diarrhea: a prospective

Bo Kyung Yang1, Byung Ju Do1, Eun Jung Kim1

  • 1Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.

Gut and Liver
|February 12, 2014
PubMed
Abstract

Insights

Simple risk factors like older age, proton pump inhibitor use, cephalosporin use, and cancer can predict pseudomembranous colitis (PMC) in hospital-acquired diarrhea (HAD) patients. Identifying these factors helps manage PMC risk.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Increasing global incidence and mortality rates of pseudomembranous colitis (PMC).
  • Need for simple predictive risk factors for PMC in hospital-acquired diarrhea (HAD) patients.

Purpose of the Study:

  • To identify easily predictable clinical risk factors for PMC in patients with HAD.

Main Methods:

  • Prospective recruitment of presumed HAD patients.
  • Multivariate logistic regression analysis to identify independent risk factors.

Main Results:

  • Independent risk factors for PMC identified: age ≥70 (OR 1.76), proton pump inhibitor use (OR 4.07), cephalosporin use (OR 2.99), and underlying cancer (OR 1.72).
  • Low prevalence of PMC in HAD patients lacking these identified risk factors.

Conclusions:

  • Key risk factors for PMC in HAD patients include cephalosporin and proton pump inhibitor use, advanced age, and cancer.
  • Strong negative predictive values suggest delaying endoscopic evaluation in HAD patients without these risk factors.
Keywords:
Clostridium difficileEnterocolitis, pseudomembranousPredictorsRisk factors

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