In vitro induced CD8+ regulatory T cells inhibit skin inflammation
European Journal of Microbiology & Immunology
|February 12, 2014
Summary
CD8(+) regulatory T cells can be induced to suppress skin inflammation. Their frequency is altered in psoriasis, suggesting a therapeutic role in skin disorders.
Area of Science:
- Immunology
- Dermatology
Background:
- CD8(+) regulatory T cells are implicated in autoimmune diseases.
- Their role in skin inflammation and psoriasis is not well understood.
Purpose of the Study:
- To investigate the capacity of CD8(+) regulatory T cells to inhibit skin inflammation in a mouse model.
- To determine the frequency of these cells in psoriasis patients.
Main Methods:
- Induction of murine CD8(+) regulatory T cells using TGF-β and retinoic acid (RA).
- Assessment of in vitro induced CD8(+) regulatory T cell function in vivo.
- Analysis of CD8(+)CD25(+)Foxp3(+) T cell frequency in peripheral blood and psoriatic skin lesions.
Main Results:
- Murine CD8(+) regulatory T cells were successfully induced in vitro.
- Induced CD8(+) regulatory T cells significantly suppressed skin inflammation in vivo.
- Psoriasis patients showed decreased peripheral blood and increased lesional skin CD8(+)CD25(+)Foxp3(+) T cells.
Conclusions:
- CD8(+)CD25(+)Foxp3(+) T cells play a role in skin disorders like psoriasis.
- In vitro induction of these cells presents a potential immunotherapy for skin inflammation.
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