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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

36
DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility...
36
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

1.0K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
1.0K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

989
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
989
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

1.6K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.6K

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Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
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[Irritable bowel syndrome: a functional disorder?].

Fernando Man1, Luis María Bustos Fernández2

  • 1Servicio de Gastroenterología Hospital Nacional Alejandro Posadas Haedo, Buenos Aires, Argentina. fman@intramed.net

Acta Gastroenterologica Latinoamericana
|February 13, 2014
PubMed
Summary

Irritable bowel syndrome (IBS) is common and costly, with unclear causes. Recent research highlights the role of gut microbiota changes in IBS pathophysiology, offering new insights for a subset of patients.

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Area of Science:

  • Gastroenterology and microbiome research.
  • Investigating the complex pathophysiology of functional gastrointestinal disorders.

Context:

  • Irritable bowel syndrome (IBS) is a prevalent condition causing significant healthcare costs and lost workdays.
  • Current diagnostic approaches for IBS rely on excluding organic diseases due to the lack of specific biomarkers.
  • Multiple potential pathophysiological mechanisms have been proposed, including sensory-motor disturbances, stress, and neurochemical imbalances.

Purpose:

  • To review and synthesize published evidence on the role of gut microbiota in irritable bowel syndrome (IBS).
  • To explore emerging insights into IBS mechanisms, particularly those related to microbial changes.

Summary:

  • Gut microbiota alterations are increasingly recognized as a significant factor in IBS.
  • Studies on small intestinal bacterial overgrowth, antibiotic effects, post-infectious IBS, probiotics, and carbohydrate malabsorption shed light on microbial contributions.
  • These mechanisms may explain IBS in a specific patient subgroup.

Impact:

  • Advances understanding of IBS pathophysiology beyond traditional models.
  • May lead to novel diagnostic strategies and targeted therapeutic interventions focusing on the gut microbiome.
  • Highlights the importance of considering microbial factors in functional gastrointestinal disorders.