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Updated: May 3, 2026
Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
Published on: September 17, 2014
[Descemet's stripping automated endothelial keratoplasty for endothelial failure after penetrating keratoplasty]
Satoru Nakatani1, Akira Murakami2
1Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. satoru-n@juntendo.ac.jp
Purpose:
To evaluate the outcome of Descemet's stripping automated endothelial keratoplasty (DSAEK) in eyes with endothelial failure after penetrating keratoplasty (PK).
Subjects And Methods:
DSAEK was performed on 13 eyes of 13 patients with failed PK. Their mean age was 73.2 years. Evaluation of visual acuity, subjective astigmatism, corneal endothelial cell density, and complications was performed.
Results:
In four eyes, PK was performed after previous surgery for hypometropia by Sato's anterior-posterior radial keratotomy. Mean followup time was 20.3 +/- 8.6 months. Mean logarithmic minimum angle of resolution (logMAR) visual acuity was 1.92 before DSAEK and 0.89 at final follow-up. Mean subjective astigmatism was 5.10 +/- 3.09D before surgery and 7.25 +/- 4.16 D at 6 months postoperatively. Mean corneal endothelial cell density at 6, 12, 24 months after DSAEK was 42.8%, 51.3%, 72.1%, respectively. Regarding postoperative complications, air was reinjected in four eyes, persistent epithelial defect and rejection occurred in one eye each, and PK was repeated in three eyes.
Conclusion:
DSAEK rapidly improved visual acuity after failed PK, but some eyes required repeat PK. Eligibility criteria for DSAEK after failed PK should be established.
