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Updated: May 3, 2026

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
Published on: February 2, 2024
Dialysis and acute kidney injury: current evidence
1Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Abstract:
Optimization of renal replacement therapy (RRT) for severe acute kidney injury (AKI) has been intensively studied over the last decade. Several large recently published randomized trials have clarified uncertainties regarding dialysis modality selection as well as dialysis dosage. This information will help inform decision makers regarding resource allocation and establishment of treatment targets. The decision to initiate dialysis remains a clinical one, based on individual patient needs. Despite technological advances in renal replacement therapy, AKI continues to be associated with poor outcomes.
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Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis

