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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Related Experiment Video

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A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
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Label-free cell phenotypic drug discovery.

Ye Fang1

  • 1Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, New York 14831, USA. fangy2@corning.com.

Combinatorial Chemistry & High Throughput Screening
|February 13, 2014
PubMed
Summary

Phenotypic screening aids drug discovery by examining small molecules in cells and organisms. Label-free cell profiling offers a novel approach for identifying potential drug candidates.

Area of Science:

  • Drug discovery and development
  • Cellular biology
  • Chemical biology

Background:

  • Phenotypic screening is crucial for identifying novel small molecule probes and drugs.
  • It allows the interrogation of molecules with native targets and biological pathways.
  • Label-free cell phenotypic profiling is an emerging alternative technology for drug discovery.

Purpose of the Study:

  • To provide the rationale behind phenotypic screening.
  • To discuss the fundamental principles of label-free cell phenotypic profiling technologies.
  • To offer guidelines for utilizing these techniques in drug discovery.

Main Methods:

  • Review of existing literature on phenotypic screening.
  • Explanation of label-free cell phenotypic profiling technologies.

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  • Discussion of practical applications and guidelines for implementation.

    • Main Results:

    • Phenotypic screening offers a powerful approach for drug discovery.
    • Label-free technologies provide a label-free alternative for cellular profiling.
    • Guidelines are provided for effective application of these methods.

    Conclusions:

    • Phenotypic screening remains a valuable strategy in drug discovery.
    • Label-free cell profiling technologies present a promising advancement.
    • The integration of these techniques can accelerate the discovery of new therapeutics.