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Updated: May 3, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Efficient and regioselective synthesis of novel functionalized dispiropyrrolidines and their cytotoxic activities
Jin-Ming Yang1, Yu Hu, Qiang Li
1School of Pharmacy, Yancheng Teachers University , Yancheng 224051, P. R. China.
Abstract:
An efficient and regioselective synthesis of novel functionalized dispiropyrrolizidine derivatives via a three-component [3 + 2] cycloaddition reaction of azomethine ylides is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. Many of these compounds were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have good activities.
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