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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: May 3, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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AB0 incompatible kidney transplantation using unspecific immunoadsorption.

Heiko Hickstein1, Sebastian Koball1, Renate Lehmann2

  • 1Universität Rostock, Med. Klinik II, Sektion Nephrologie, Germany.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|February 13, 2014
PubMed
Summary

Ig-TheraSorb immunoadsorption effectively removes isoagglutinins, enabling successful ABO-incompatible kidney transplants. This method offers a viable alternative for patients, improving transplant outcomes.

Keywords:
ABO incompatible transplantationImmunoadsorptionIsoagglutinin-antibodyKidney transplantationPlasmapheresis

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Last Updated: May 3, 2026

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Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Background:

  • ABO-incompatible kidney transplantation protocols often involve antigen-specific immunoadsorption, rituximab, and immunosuppression.
  • Established protocols are used in many European centers.
  • An alternative isoagglutinin elimination method is presented.

Observation:

  • The Ig-TheraSorb immunoadsorption system was used for an ABO-incompatible living donor kidney transplant.
  • Five preoperative and one postoperative treatment sessions were performed.
  • Twice the patient's calculated plasma volume (4400 ml) was treated per session.

Findings:

  • Immunoadsorption significantly reduced IgM isoagglutinin titers from 1:16 to 1:1 and IgG isoagglutinin titers from 1:32 to 1:2.
  • The procedure was well-tolerated with no reported side effects.
  • The patient maintained good renal function 500 days post-transplantation.

Implications:

  • Ig-TheraSorb immunoadsorption provides an effective alternative for removing harmful antibodies.
  • This method facilitates the integration of ABO-incompatible kidney transplantation into standard transplant programs.
  • Successful application demonstrates the potential for improved patient outcomes in ABO-incompatible transplants.