Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

52
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rethinking Perioperative Care in Older Adults: A Plea for Specialization.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026
Same author

A phenylketonuria mouse model exhibits EEG spike-wave discharges: Effects of sleep deprivation and low-Phe diet.

Neurobiology of disease·2026
Same author

Tracing the dynamics of treatment decision-making: A qualitative study about older patients' treatment decision-making and retrospective evaluation.

Journal of geriatric oncology·2026
Same author

Acute and short-term effects of all-type whole-body exercise on cortical oxygenated hemoglobin concentrations in healthy adults: A systematic review and meta-analysis.

Behavioural brain research·2026
Same author

A Multicenter Evaluation of Sex-Specific Differences in Pre-Hospital Care and Patient Outcome of Severe Traumatic Brain Injury: A Multicenter Cohort Study.

Journal of neurotrauma·2026
Same author

Periodic limb movements during sedation and general anesthesia in elderly patients: a prospective observational study.

Journal of clinical monitoring and computing·2026

Related Experiment Video

Updated: May 3, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

19.7K

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning.

Iris B Hovens1, Regien G Schoemaker1, Eddy A van der Zee1

  • 1Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.

Brain, Behavior, and Immunity
|February 13, 2014
PubMed
Summary

Surgery temporarily impairs spatial learning and memory in young rats by causing neuroinflammation and reducing brain-derived neurotrophic factor (BDNF). These changes highlight the vulnerability of hippocampal-dependent cognition to surgical stress.

Keywords:
Brain-derived neurotrophic factorExploratory behaviorLearning and memoryNeurogenesisNeuroinflammationPostoperative cognitive dysfunctionSurgery

More Related Videos

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.0K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K

Related Experiment Videos

Last Updated: May 3, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

19.7K
A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.0K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Science

Background:

  • Postoperative cognitive dysfunction (POCD) is linked to surgery-induced inflammation.
  • Inflammation may affect neuronal function via pathways like brain-derived neurotrophic factor (BDNF).

Purpose of the Study:

  • To investigate the time course of neuroinflammation, BDNF pathway changes, and POCD after abdominal surgery in rats.
  • To determine the impact of surgery on cognition, mood, and related biological markers.

Main Methods:

  • Young male Wistar rats underwent abdominal surgery with jugular vein catheterization for blood sampling.
  • Cognition, affective behavior, neuroinflammation markers, BDNF, and neurogenesis were assessed at 1, 2, and 3 weeks post-surgery.

Main Results:

  • Surgery induced temporary spatial learning and memory deficits, peaking in the first two weeks.
  • Elevated IL-6 plasma levels correlated with postoperative behavioral changes.
  • Brain analysis revealed increased neuroinflammation, decreased BDNF, and reduced neurogenesis up to 3 weeks post-surgery.

Conclusions:

  • Hippocampal-dependent spatial cognition is particularly vulnerable to surgery-induced impairment in young rats.
  • Postoperative neuroinflammation, altered BDNF, and reduced neurogenesis are potential mechanisms underlying POCD.
  • Cognitive dysfunction and mood changes appear to be distinct features of postoperative behavioral impairment.