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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

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Individualizing osteoporosis medications.

Stuart Silverman1

  • 1From the Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, OMC Clinical Research Center, Los Angeles, California.

Menopause (New York, N.Y.)
|February 13, 2014
PubMed
Summary
This summary is machine-generated.

This clinical scenario presents a 58-year-old postmenopausal woman with osteopenia and fracture risk factors. Treatment should address her symptoms and bone health to prevent osteoporosis progression.

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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Area of Science:

  • Gerontology
  • Endocrinology
  • Bone Metabolism

Background:

  • Postmenopausal women are at increased risk for osteoporosis due to estrogen deficiency.
  • Low bone mass (osteopenia) is a precursor to osteoporosis and increases fracture risk.

Observation:

  • The patient is a 58-year-old postmenopausal woman experiencing hot flashes and night sweats.
  • She has a T-score of -2.4 in the femoral neck, indicating osteopenia.
  • She has a parental history of hip fracture and a 10-year major osteoporotic fracture risk of 18%.

Findings:

  • The patient's FRAX score indicates a significant risk for major osteoporotic and hip fractures, meeting treatment thresholds.
  • Current calcium and vitamin D intake may be insufficient for optimal bone health in this demographic.

Implications:

  • Pharmacological intervention for osteoporosis may be indicated in addition to lifestyle modifications.
  • Effective management can reduce fracture risk and improve quality of life in postmenopausal women.
  • Personalized treatment plans are crucial for addressing individual risk factors and symptoms.