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Oral squamous cell carcinomas in age distinct population: a comparison of p53 immunoexpression
Akhilesh Chandra1, Anil Singh, Bastian Thattil Sebastian
1Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Aims:
The study aimed to assess the diffused expression of p53 protein in patients with OSCC and its association with age at diagnosis (using 50 years as a cut point).
Study Design:
Ten normal oral mucosa and sixty OSCC lesions from age-distinct patient populations were immunohistochemically analyzed for the expression of p53 protein.
Results:
In OSCC cases, 31 out of total 60 cases (51.67%) showed positive expression for p53 protein and it was more common in older study group (56.67%) than in younger study group (46.67%) but the difference was not statistically significant. Moreover, there was also no significant difference in the p53 indices (percentage of p53 positive cells) between the two study groups (P = 0.827).
Conclusion:
The alteration rates were found to be slightly higher in older patients although not statistically significant.
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