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Hepatic hyaline globules associated with passive congestion
E C Klatt1, M N Koss, T S Young
1Department of Pathology, Los Angeles County-University of Southern California Medical Center 90033.
Archives of Pathology & Laboratory Medicine
|May 1, 1988
Summary
Hyaline globules in liver, linked to hepatic congestion, were found in 15% of autopsies. These PAS-positive globules contain imbibed serum proteins, differing from alpha 1-antitrypsin disease globules.
Area of Science:
- Hepatology
- Pathology
- Biochemistry
Background:
- Hyaline globules in hepatocytes are uncommon findings.
- Their exact nature and origin remain incompletely understood.
- Distinguishing them from disease-specific globules is crucial.
Purpose of the Study:
- To characterize hyaline globules found in liver tissue associated with hepatic congestion.
- To investigate the composition and potential etiology of these globules.
- To determine their prevalence in adult autopsies.
Main Methods:
- Light microscopy with Periodic Acid-Schiff (PAS) staining and diastase digestion.
- Electron microscopy for ultrastructural analysis.
- Immunohistochemical staining for fibrinogen and alpha 1-antitrypsin.
Main Results:
- Hyaline globules were identified in hepatocytes in 15% of 100 adult autopsies.
- Globules were PAS-positive and diastase-resistant.
- Electron microscopy revealed microfibrillar material; immunohistochemistry showed positivity for fibrinogen and alpha 1-antitrypsin.
- The findings suggest globules are phagosomes of imbibed serum proteins due to passive congestion.
Conclusions:
- Hyaline globules associated with hepatic congestion are more common than previously thought.
- Their composition suggests an origin from imbibed serum proteins.
- These globules must be differentiated from alpha 1-antitrypsin disease globules.