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Related Experiment Videos

Epithelioid sarcoma. An electron-microscopic and immunohistochemical study.

S Persson1, L G Kindblom, L Angervall

  • 1Department of Pathology, Sahlgren Hospital, University of Göteborg, Sweden.

Applied Pathology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Epithelioid sarcoma cells show features of both epithelial and mesenchymal cells. Immunohistochemistry and electron microscopy reveal cytokeratins, epithelial membrane antigen, actin, and vimentin, suggesting a dual origin.

Area of Science:

  • Oncology
  • Pathology
  • Cell Biology

Background:

  • Epithelioid sarcoma is a rare soft tissue tumor.
  • Its precise cellular origin remains debated, with features suggesting both epithelial and mesenchymal differentiation.

Purpose of the Study:

  • To investigate the light microscopic, electron microscopic, and immunohistochemical characteristics of epithelioid sarcoma.
  • To clarify the potential cellular origin and differentiation pathways of this tumor.

Main Methods:

  • Light and electron microscopy were performed on 7 epithelioid sarcoma cases.
  • Immunohistochemical analysis utilized antibodies against cytokeratins, epithelial membrane antigen (EMA), human milk fat globule (HMFG), actin, and vimentin.

Main Results:

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  • All tumors expressed cytokeratins, EMA, actin, and vimentin.
  • Electron microscopy showed tumor cells with features like pinocytic vesicles, desmosome-like junctions, and intermediate filaments.
  • Some cells displayed dense cytoplasmic bodies formed by intermediate filaments.

Conclusions:

  • Epithelioid sarcoma cells exhibit immunohistochemical and ultrastructural similarities to epithelial cells.
  • Despite these findings, a mesenchymal origin cannot be excluded.
  • The study highlights the complex differentiation of epithelioid sarcoma.