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Lipoprotein (a) and plasminogen are immunochemically related
I Karàdi1, G M Kostner, A Gries
13rd Department of Medicine, Semmelweis Medical School, Budapest, Hungary.
Biochimica Et Biophysica Acta
|May 2, 1988
Summary
Lipoprotein (a) shares similarities with plasminogen, including immunochemical relation and lysine-binding properties. This finding suggests potential roles in fibrinolysis and atherogenicity.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Proteomics
Background:
- Lipoprotein (a) is a highly atherogenic lipoprotein.
- Previous research indicated lipoprotein (a) possesses proteolytic activity.
Purpose of the Study:
- To investigate the relationship between apoprotein (a) and plasminogen.
- To explore the functional similarities between lipoprotein (a) and plasminogen.
Main Methods:
- Immunochemical analysis using polyclonal and monoclonal antibodies.
- Adsorption studies with immunospecific anti-lipoprotein (a) columns.
- Lysine-Sepharose binding assays.
- Fibrinolytic activity assays with streptokinase.
Main Results:
- Aprotein (a) demonstrated immunochemical similarity to plasminogen.
- Lipoprotein (a) was adsorbed by anti-lipoprotein (a) columns, indicating plasminogen adsorption from plasma.
- Lipoprotein (a) exhibited selective binding to lysine-Sepharose, albeit with lower affinity than plasminogen.
- Lipoprotein (a) prolonged fibrinolysis time in a streptokinase-challenged system.
Conclusions:
- Lipoprotein (a) is immunochemically related to plasminogen.
- Lipoprotein (a) shares functional similarities with plasminogen, including lysine binding.
- These findings suggest a potential role for lipoprotein (a) in fibrinolysis and cardiovascular disease.