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Updated: May 3, 2026

Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch
Published on: April 21, 2023
Endothelial shear stress and blood viscosity in peripheral arterial disease
Young I Cho1, Daniel J Cho, Robert S Rosenson
1Department of Mechanical Eng. and Mechanics, Drexel University, 3141 Chestnut Street, Philadelphia, PA, 19104, USA, choyi@drexel.edu.
Abstract:
This review examines the emerging role of endothelial shear stress (ESS) and blood viscosity on the initiation and progression of atherosclerosis in peripheral arterial disease. Among the variables determining ESS, blood viscosity has to date been the most overlooked by clinical researchers. Blood viscosity is a laboratory assessment that is minimally invasive and modifiable using pharmacologic therapy as well as by hemodilution. Monitoring and controlling blood viscosity not only modulates ESS, but also reduces peripheral vascular resistance and increases blood flow to the lower extremities.
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