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Related Experiment Video

Updated: May 3, 2026

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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High-intensity interval training induces a modest systemic inflammatory response in active, young men.

Kevin A Zwetsloot1, Casey S John1, Marcus M Lawrence1

  • 1Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA.

Journal of Inflammation Research
|February 13, 2014
PubMed
Summary

High-intensity interval training (HIIT) acutely increases inflammatory cytokines like IL-6. However, two weeks of HIIT does not change this inflammatory response in recreationally active men.

Keywords:
cycle ergometerexercise traininginflammatory cytokines

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Area of Science:

  • Exercise physiology
  • Immunology
  • Sports science

Background:

  • High-intensity interval training (HIIT) is a popular exercise modality.
  • Understanding the inflammatory response to HIIT is crucial for optimizing training protocols.
  • Previous research has yielded mixed results on HIIT's systemic inflammatory effects.

Purpose of the Study:

  • To investigate the acute systemic inflammatory response to a single high-intensity interval training session.
  • To determine if two weeks of consistent HIIT alters the inflammatory response to subsequent acute exercise bouts.
  • To examine changes in inflammatory markers in recreationally active young males.

Main Methods:

  • Eight recreationally active males completed six HIIT sessions over two weeks.
  • HIIT involved 8-12 intervals at 100% peak oxygen uptake (VO2max) on a cycle ergometer.
  • Serum samples were analyzed for inflammatory cytokines and chemokines (e.g., IL-6, TNF-α) at rest and post-exercise.

Main Results:

  • An acute HIIT session significantly increased levels of IL-6, IL-8, IL-10, TNF-α, and MCP-1.
  • Interferon-γ, GM-CSF, and IL-1β concentrations remained unchanged after an acute HIIT bout.
  • Two weeks of HIIT training did not significantly alter the inflammatory response to a subsequent acute HIIT session.
  • Maximal power output increased by 4.6% after two weeks, but VO2max did not improve.

Conclusions:

  • Acute HIIT elicits a transient inflammatory response in young, active males.
  • Two weeks of HIIT does not lead to systemic inflammation adaptation in this population.
  • HIIT may enhance maximal power output without significant changes in inflammatory markers over a short training period.