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Updated: May 3, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
Published on: April 5, 2016
Tissue engineering is a promising method for the repair of spinal cord injuries (Review)
Wenchen Ji1, Shouye Hu2, Jiao Zhou3
1Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China ; Department of Physiology, College of Medicine, University of Sydney, Sydney 2006, Australia.
Abstract:
Spinal cord injury (SCI) may lead to a devastating and permanent loss of neurological function, which may place a great economic burden on the family of the patient and society. Methods for reducing the death of neuronal cells, inhibiting immune and inflammatory reactions, and promoting the growth of axons in order to build up synapses with the target cells are the focus of current research. Target cells are located in the damaged spinal cord which create a connect with the scaffold. As tissue engineering technology is developed for use in a variety of different areas, particularly the biomedical field, a clear understanding of the mechanisms of tissue engineering is important. This review establishes how this technology may be used in basic experiments with regard to SCI and considers its potential future clinical use.
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