Relationship between Endometrial Thickness and In Vitro Fertilization-Intracytoplasmic Sperm Injection Outcome

This study assessed the relationship between endometrial thickness on day of human chorionic gonadotropin (hCG) administration and in vitro fertilizationintracytoplasmic sperm injection (IVF-ICSI).

This prospective cross-sectional study included a total of 593 women. Patients were treated with either the agonist or antagonist protocol according to the clinician's and patient's preference. Endometrial thickness on the hCG day was measured by transvaginal ultrasonography (TV-USG). Patients were divided into four groups according to endometrial lines, as follows: <7 mm (group 1), 7-10 mm (group 2), 10-14 mm (group 3), and >14 mm (group 4).

Implantation rate (IR), clinical pregnancy rate (CPR), and ongoing pregnancy rate (OPR) were significantly lower in group 1 than the other three groups (p<0.05). However, there was no significant difference among groups 2, 3 and 4. Although the endometrial line in the agonist protocol was higher than in the antagonist protocol, the difference was not statistically significant.

The chance of pregnancy appears to be lower in individuals with endometrial thickness less than 7 mm compared with those of higher value.