Nephrotic sydrome developing in severe ovarian hyperstimulation syndrome
Funda Gungor Ugurlucan1, Burcin Karamustafaoglu1, Ahmet Cem Iyibozkurt1
1Department of Obstetrics and Gynecology, Istanbul University, Istanbul Medical School, Istanbul, Turkey.
International Journal of Fertility & Sterility
|February 13, 2014
Summary
A rare case of nephrotic syndrome developed during severe ovarian hyperstimulation syndrome hospitalization. This complication, presenting with proteinuria and IgA nephropathy, is unprecedented in medical literature.
Area of Science:
- Nephrology
- Reproductive Endocrinology
Background:
- Severe ovarian hyperstimulation syndrome (OHSS) can lead to significant fluid shifts and organ compromise.
- Nephrotic syndrome is a kidney disorder characterized by heavy protein loss in the urine.
Purpose of the Study:
- To report a unique case of nephrotic syndrome developing during hospitalization for severe OHSS.
- To document the clinical, biochemical, and histological findings of this rare complication.
Main Methods:
- Case presentation of a patient hospitalized for severe OHSS.
- Clinical monitoring including assessment of ascites and respiratory distress.
- 24-hour urine protein analysis.
- Renal biopsy for histological examination.
Main Results:
- The patient developed nephrotic syndrome during OHSS management.
- Significant proteinuria was detected.
- Renal biopsy revealed global and segmental glomerulosclerosis, mesangial arteritis, and visceral epithelial cell proliferation consistent with IgA nephropathy.
Conclusions:
- Nephrotic syndrome is a potential, albeit rare, complication of severe OHSS.
- IgA nephropathy was identified as the underlying renal pathology in this case.
- This represents the first reported instance of nephrotic syndrome occurring in the context of severe OHSS.
Keywords:
AscitesIn vitro Fertilization (IVF)Nephrotic SyndromeOvar- ian StimulationOvarian Hyperstimulation SyndromeMore Related Videos
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