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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Natural compounds as anticancer agents: Experimental evidence.

Jiao Wang1, Yang-Fu Jiang1

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|February 13, 2014
PubMed
Summary
This summary is machine-generated.

Natural compounds like curcumin and resveratrol show promise in cancer chemoprevention. Research indicates these agents can suppress premalignant lesions, offering a potential strategy for lowering cancer incidence through lifestyle and dietary interventions.

Keywords:
(-)-Epigallocatechin-3-gallateCancerChemopreventionCurcuminIndole-3-carbinolNatural agentsResveratrolVitamin D

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Area of Science:

  • Oncology
  • Preventive Medicine
  • Natural Product Chemistry

Background:

  • Cancer prevention is a global health priority.
  • Lifestyle factors significantly influence cancer risk.
  • Cancer chemoprevention using natural agents is an evolving field.

Purpose of the Study:

  • To review experimental data on the chemopreventive and tumor-suppressive effects of natural compounds.
  • To highlight the potential of dietary phytochemicals and other natural agents in cancer prevention.

Main Methods:

  • Summary of experimental findings from animal models.
  • Review of clinical trial data on natural agents for malignancy.
  • Focus on specific compounds: curcumin, EGCG, resveratrol, indole-3-carbinol, and vitamin D.

Main Results:

  • Natural compounds like curcumin, (-)-epigallocatechin-3-gallate (EGCG), and resveratrol demonstrate chemopreventive activity in animal models.
  • These agents have shown potential in reversing or suppressing premalignant lesions.
  • Clinical trials are evaluating the safety and efficacy of these natural compounds in humans.

Conclusions:

  • Natural compounds offer a promising avenue for cancer chemoprevention.
  • Dietary phytochemicals and other natural agents warrant further investigation for their role in reducing cancer incidence.
  • A healthy lifestyle incorporating these agents may contribute to cancer prevention strategies.