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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
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[Isolation and characterization of rotavirus from bat]
Le-Le Xia1, Biao He2, Ting-Song Hu3
1College of Animal Science and Technology, Jilin Agriculturral University, Changchun 130118, China. xialele6@163.com
Bing Du Xue Bao = Chinese Journal of Virology
|February 14, 2014
Summary
Bats carry novel rotaviruses (RVA) that can infect humans. This study identified a new RVA strain in Stoliczka's trident bats, highlighting their role as potential viral reservoirs.
Area of Science:
- Virology
- Genomics
- Zoonotic Diseases
Context:
- Bats are known reservoirs for various viruses with zoonotic potential.
- Insectivorous bats, specifically Stoliczka's trident bats, were sampled in Yunnan Province.
- Previous research indicates bats harbor diverse viral pathogens.
Purpose:
- To investigate the presence of novel viruses in bat gut and lung tissues using viral metagenomic analysis.
- To identify and characterize rotavirus (RVA) strains in bats.
- To assess the zoonotic potential of bat-borne RVAs.
Summary:
- Viral metagenomic analysis of 30 insectivorous bats revealed 26 reads belonging to group A rotavirus (RVA).
- RT-PCR and cell culture isolation confirmed a novel RVA strain, RVA/Bat-tc/MYAS33/2013/G3P[10], in one bat.
- The novel RVA strain exhibited genetic similarities to equine and human RVA strains, with its VP7 gene related to an equine strain and its VP4 gene to a human strain.
Impact:
- This study demonstrates that bats can act as reservoirs for group A rotaviruses.
- The findings underscore the importance of bats in the ecology of rotaviruses, including those with potential human health implications.
- Identification of a novel RVA with mixed genetic origins (equine and human) raises concerns about viral reassortment and zoonotic transmission.
