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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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[From "different patterns in the same disease" to "analogous patterns in the same disease"].

Wen-Jian Wang1, Zi-Yin Shen2

  • 1Institute of Integrative Medicine, Fudan University, Shanghai 200040, China. wj6518@163.com

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|February 14, 2014
PubMed
Summary

The "analogous patterns in the same disease" theory refines integrative medicine by identifying major patterns and subtypes for diseases. This approach improves the treatment of commonalities and individual differences in patients.

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Area of Science:

  • Integrative Medicine
  • Traditional Chinese Medicine (TCM)
  • Western Medicine (WM)

Context:

  • The relationship between Western Medicine (WM) disease and Traditional Chinese Medicine (TCM) pattern is crucial for integrative medicine (IM).
  • The 'different patterns in the same disease' theory, while advancing IM and TCM modernization, faces clinical misinterpretations.
  • Overemphasis on individual differences neglects commonalities in patients with the same disease, weakening pattern identification and treatment.

Purpose:

  • To introduce and elucidate the theory of 'analogous patterns in the same disease' as a refinement of existing IM and TCM concepts.
  • To address the misinterpretations of 'different patterns in the same disease' by integrating pathogenesis, manifestations, and pathological changes.
  • To establish a framework for identifying major patterns and analogous subtypes within a disease for targeted therapeutic strategies.

Summary:

  • The theory of 'analogous patterns in the same disease' integrates 'different patterns in the same disease' with 'microcosmic identification of patterns'.
  • It reveals TCM's core mechanisms by analyzing pathogenesis and identifying major patterns based on clinical manifestations and pathological changes.
  • Major formulas are prescribed for major patterns, while analogous subtypes are treated with modified formulas, addressing individual variations.

Impact:

  • Clarifies the intrinsic relationship between disease and pattern in TCM.
  • Perfects and develops the theory of 'different patterns in the same disease'.
  • Represents a significant innovation in IM thinking and research methodologies.