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Nitric oxide system and diabetic nephropathy
Bruno Schmidt Dellamea1, Cristiane Bauermann Leitão, Rogério Friedman
1Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. brunodellamea@gmail.com.
Diabetology & Metabolic Syndrome
|February 14, 2014
Summary
Nitric oxide synthase (NOS) plays a role in diabetic nephropathy (DN) development. While research on endothelial NOS (eNOS) gene variants and DN is contradictory, NOS remains a potential factor in kidney disease progression.
Area of Science:
- Nephrology
- Genetics
- Biochemistry
Background:
- Diabetic nephropathy (DN) affects 30% of type 2 diabetes patients, leading to kidney failure.
- DN pathogenesis involves hyperglycemia, environmental, and genetic factors.
- Nitric oxide (NO), produced by nitric oxide synthase (NOS), is crucial for endothelial and kidney function.
Purpose of the Study:
- To review the role of nitric oxide synthase (NOS) in the pathogenesis of diabetic nephropathy (DN).
- To examine the potential link between endothelial NOS (eNOS) gene variants and DN susceptibility.
Main Methods:
- Literature review of studies on NOS, NO, and DN.
- Focus on eNOS gene polymorphisms: G894T, intron 4 repeat, and T786C SNP.
- Analysis of research linking eNOS variants to DN induction and progression.
Main Results:
- NO is vital for renal hemodynamics, natriuresis, diuresis, and blood pressure homeostasis.
- eNOS gene variants have been investigated as potential DN susceptibility factors.
- Studies on eNOS gene polymorphisms and DN have yielded conflicting results.
Conclusions:
- NOS appears to be involved in the development and progression of DN.
- Despite discrepant findings, the eNOS gene is considered a viable candidate for DN susceptibility.
- Further research is needed to clarify the precise role of NOS in DN pathogenesis.
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