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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Formation of Dispersible Taohong Siwu Tablets
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Safe to crush? A pilot study into solid dosage form modification in aged care.

Nicole Mercovich1, Greg J Kyle, Mark Naunton

  • 1Discipline of Pharmacy, University of Canberra, Canberra, Australian Capital Territory, Australia.

Australasian Journal on Ageing
|February 14, 2014
PubMed
Summary
This summary is machine-generated.

Medication crushing in aged care facilities (ACFs) is often inappropriate, leading to drug mixing and incomplete doses. Enhanced staff training on using available resources is crucial to improve medication safety for residents.

Keywords:
aged carealtered pharmacokineticsdosage form modificationdysphagiamedication administration

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Area of Science:

  • Geriatric Pharmacy
  • Medication Management
  • Aged Care Quality

Background:

  • Medication administration in aged care facilities (ACFs) presents unique challenges.
  • Solid dosage form modification, such as crushing tablets, is common but carries risks.
  • Assessing current practices and staff knowledge is vital for resident safety.

Purpose of the Study:

  • To observe medication solid dosage form modification practices in ACFs.
  • To evaluate nursing staff's self-perceived knowledge regarding medication modification.
  • To identify the resources available to staff for medication modification.

Main Methods:

  • Direct observation of medication rounds in Australian Capital Territory ACFs.
  • Assessment of nursing staff's knowledge of medication dosage form modification.
  • Evaluation of available resources for medication modification.

Main Results:

  • 75 medications were modified across 160 observations, with 32% deemed inappropriate.
  • Crushing techniques led to drug mixing, spillage, and incomplete dosing.
  • Staff reported adequate resources but lacked knowledge on their effective use.

Conclusions:

  • A high incidence of inappropriate medication crushing was observed.
  • Inadequate knowledge of resource utilization contributes to unsafe practices.
  • Targeted staff training is essential to improve medication modification safety in ACFs.