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Related Experiment Video

Updated: May 3, 2026

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HHV-8 seroprevalence: a global view.

Eliane Rohner1, Natascha Wyss, Sven Trelle

  • 1Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. erohner@ispm.unibe.ch.

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Summary

This study systematically reviews Human Herpes Virus 8 (HHV-8) global prevalence and risk factors, including HIV status. Findings will enhance understanding of HHV-8 epidemiology and inform prevention strategies for associated cancers like Kaposi sarcoma.

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human Herpes Virus 8 (HHV-8) is the causative agent of Kaposi sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease.
  • KS represents a significant disease burden in regions with high HHV-8 seroprevalence.
  • Elevated HHV-8 prevalence is observed in men who have sex with men (MSM) and migrants from endemic areas outside these regions.

Purpose of the Study:

  • To conduct a systematic literature review and meta-analysis to define the global distribution of HHV-8 seroprevalence.
  • To identify risk factors associated with HHV-8 infection, with a specific focus on the correlation with HIV status.

Main Methods:

  • Inclusion of observational studies reporting HHV-8 seroprevalence data in children and adults worldwide, excluding case reports/series and studies with <50 participants.
  • Systematic searches of MEDLINE, EMBASE, and conference proceedings without language restrictions.
  • Data extraction by two independent reviewers, followed by fully Bayesian meta-analysis with random effects to pool seroprevalence and odds ratios for HIV association.

Main Results:

  • The systematic review and meta-analysis will provide a comprehensive overview of global HHV-8 seroprevalence.
  • Identification and quantification of key risk factors for HHV-8 infection, particularly the association with HIV status.
  • Exploration of heterogeneity through subgroup and meta-regression analyses based on various demographic, clinical, and methodological factors.

Conclusions:

  • The study aims to refine the understanding of global HHV-8 seroprevalence and its associated risk factors.
  • Improved insights into HHV-8 epidemiology are expected, potentially guiding the development of targeted prevention measures.
  • Findings could contribute to reducing the burden of HHV-8-associated malignancies, including Kaposi sarcoma.