Adenylyl cyclases in the digestive system
Maria Eugenia Sabbatini1, Fred Gorelick2, Shannon Glaser3
1Department of Biological Sciences, Georgia Regents University, United States.
Abstract:
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
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