Related Experiment Video
Updated: May 3, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
[Treatment options for elderly breast cancer patients over 70 years old]
1Breast Center, Beijing Hospital, Ministry of Health, Beijing 100730, China.
Objective:
To analyze the clinical characteristics and therapeutics of elderly patients with breast carcinomas.
Methods:
A total of 312 patients ( ≥ 70 years old) admitted into Breast Center of Beijing Hospital from September 1997 to September 2011 were included for this retrospective study. Their clinical characteristics, treatment options and prognostic factors were analyzed.
Results:
They accounted for 14.6% (312/2137) of breast cancer patients treated during the same period. The predominant complaint was palpable mass (n = 250, 80.1%). 90.4% (n = 282) of them were complicated with other diseases. The major pathologic type was invasive ductal carcinoma of non-special type (n = 248, 79.5%). The positive rate of estrogen receptor (ER) and(or) progesterone receptor (PR) was 75.3% (n = 235), and 15.7% (n = 49) cases were Cerb-B2 (+ + +) . The 5, 10-year overall survival were 75.0% and 41.8% respectively. TNM stage, vascular thrombosis, operative regimen and adjuvant therapy were prognostic factors.
Conclusions:
Surgical operation and endocrine therapy are the first choice remedies for elderly patients. And the major prognostic factors are TNM stage, vascular thrombosis and treatment regimens.
Related Concept Videos
Drug Dosing: Geriatric Patients
Treatment Resistant Cancers
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistent Cancers
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

