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Non-operative versus operative treatment for blunt pancreatic trauma in children
Michael V Haugaard1, André Wettergren, Jens Georg Hillingsø
1Department of Surgery and Transplantation C2122, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK-2100 Ø
Insights
Evidence for treating severe blunt pancreatic trauma in children is lacking. This review found no randomized clinical trials, highlighting the need for multi-center studies on operative versus non-operative management.
Area of Science:
- Pediatric Surgery
- Trauma Management
- Gastrointestinal Surgery
Background:
- Pancreatic trauma in children is a severe condition associated with significant morbidity.
- Treatment options for blunt pancreatic lesions include non-operative and operative approaches.
- The optimal management strategy for severe (grade III-V) blunt pancreatic injuries in children remains unclear.
Purpose of the Study:
- To evaluate the benefits and harms of operative versus non-operative treatment for blunt pancreatic trauma in pediatric patients.
Main Methods:
- A comprehensive literature search was conducted across multiple databases including Cochrane, MEDLINE, EMBASE, and Web of Science up to June 21, 2013.
- The review aimed to include all randomized clinical trials comparing operative and non-operative management of blunt pancreatic trauma in children.
- Study eligibility was independently assessed by two review authors.
Main Results:
- The search identified 83 relevant references.
- However, no randomized clinical trials investigating the treatment of blunt pancreatic trauma in children were found and all references were excluded.
Conclusions:
- Current treatment strategies for severe blunt pancreatic trauma in children are not supported by evidence from randomized clinical trials.
- There is a critical need for multi-center trials to establish robust evidence for operative versus non-operative management in pediatric pancreatic trauma.
Background:
Pancreatic trauma in children is a serious condition with high morbidity. Blunt traumatic pancreatic lesions in children can be treated non-operatively or operatively. For less severe, grade I and II, blunt pancreatic trauma a non-operative or conservative approach is usually employed. Currently, the optimal treatment, of whether to perform operative or non-operative treatment of severe, grade III to V, blunt pancreatic injury in children is unclear.
Objectives:
To assess the benefits and harms of operative versus non-operative treatment of blunt pancreatic trauma in children.
Search Methods:
We searched the Cochrane Injuries Group's Specialised Register, Cochrane Central Register of Controlled Trials (Issue 5, 2013), MEDLINE (OvidSP), EMBASE (OvidSP), ISI Web of Science (SCI-EXPANDED and CPCI-S) and ZETOC. In addition, we searched bibliographies of relevant articles, conference proceeding abstracts and clinical trials registries. We conducted the search on the 21 June 2013.
Selection Criteria:
We planned to select all randomised clinical trials investigating non-operative versus operative treatment of blunt pancreatic trauma in children, irrespective of blinding, publication status or language of publication.
Data Collection And Analysis:
We used relevant search strategies to obtain the titles and abstracts of studies that were relevant for the review. Two review authors independently assessed trial eligibility.
Main Results:
The search found 83 relevant references. We excluded all of the references and found no randomised clinical trials investigating treatment of blunt pancreatic trauma in children.
Authors' Conclusions:
This review shows that strategies regarding non-operative versus operative treatment of severe blunt pancreatic trauma in children are not based on randomised clinical trials. We recommend that multi-centre trials evaluating non-operative versus operative treatment of paediatric pancreatic trauma are conducted to establish firm evidence in this field of medicine.
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