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A fatal case of synthetic opioid intoxication is reported. Analysis identified AH-7921 in postmortem specimens, leading to the cause of death being opioid overdose.

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Area of Science:

  • Forensic Toxicology
  • Clinical Chemistry

Background:

  • Synthetic opioids represent a growing challenge in forensic toxicology.
  • Accurate identification and quantification are crucial for determining cause and manner of death.

Observation:

  • A 19-year-old male was found deceased with no apparent anatomical cause of death.
  • Postmortem toxicological analysis detected the synthetic opioid AH-7921 in multiple biological samples.

Findings:

  • AH-7921 was quantified in heart blood (3.9 mg/L), peripheral blood (9.1 mg/L), urine (6.0 mg/L), liver (26 mg/kg), kidney (7.2 mg/kg), spleen (8.0 mg/kg), heart (5.1 mg/kg), lung (21 mg/kg), brain (7.7 mg/kg), bile (17 mg/L), and stomach content (120 mg/125 mL).
  • Gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring mode was used for analysis.

Implications:

  • This case highlights the potential lethality of novel synthetic opioids like AH-7921.
  • The findings underscore the importance of comprehensive toxicological screening in unexplained deaths.