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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Biology and Time Course of Obstruction-Induced Detrusor Underactivity Causing Postvoid Residual Urine.

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Related Experiment Video

Updated: May 3, 2026

Experimental Approaches to Tissue Engineering
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Experimental Approaches to Tissue Engineering

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Future therapies: Early trials and basic science.

Karl-Erik Andersson1

  • 1Professor, Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
|February 14, 2014
PubMed
Summary

Current overactive bladder (OAB) treatments include antimuscarinics and mirabegron. This review covers recent advancements in existing OAB therapies and promising new drug candidates.

Area of Science:

  • Urology
  • Pharmacology
  • Drug Development

Background:

  • Overactive bladder (OAB) significantly impacts quality of life.
  • Current pharmacotherapies for OAB include antimuscarinics and beta3-adrenoceptor agonists like mirabegron.

Purpose of the Study:

  • To review recent research on established OAB treatments.
  • To highlight promising novel therapeutic agents currently in development for OAB.

Main Methods:

  • Literature review of recent pharmacological research.
  • Analysis of clinical trial data for emerging OAB therapies.

Main Results:

  • Recent studies show continued efficacy and safety profiles for existing OAB medications.
  • Several novel agents targeting different pathways show promise in early-stage development.

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Conclusions:

  • Ongoing research is refining existing OAB treatments.
  • New therapeutic avenues are emerging for managing overactive bladder symptoms.