Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

8.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.4K
Introduction to Electrolytes01:33

Introduction to Electrolytes

12.5K
In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
One...
12.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

4.6K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of the most stable reference gene for RT-qPCR analysis of vitrified-warmed bovine blastocysts: Validation through gene expression analysis.

Cryobiology·2026
Same author

In Vitro Developmental Competence Predicts Pregnancy Outcomes Following Transfer of Beef Embryos to Dairy Recipients: A Retrospective Study.

Animals : an open access journal from MDPI·2026
Same author

Perceived Transparency from Dynamic Luminance Modulation in Uniform Center-Surround Displays.

Vision (Basel, Switzerland)·2026
Same author

Heat stress disrupts the ovarian microenvironment in cattle: An in vivo analysis of hormonal alterations, oxidative stress-induced apoptosis, and reduced pregnancy outcomes.

Animal reproduction science·2026
Same author

Plasma extracellular vesicles-derived MicroRNAs as potential biomarkers in idiopathic pulmonary fibrosis.

Respiratory research·2026
Same author

A pushing stick or a pulled rubber band: Material perception reverses the causal arrow in agent-patient dynamics.

Journal of experimental psychology. General·2026

Related Experiment Video

Updated: May 3, 2026

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

3.7K

Bisphosphonate-induced Severe Hypocalcemia - A Case Report -.

Won-Seok Do1, Jin-Kyung Park1, Myung-Il Park1

  • 1Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.

Journal of Bone Metabolism
|February 14, 2014
PubMed
Summary

Bisphosphonate treatment can cause severe hypocalcemia, especially in patients with renal dysfunction. Monitoring calcium levels and ensuring adequate vitamin D and calcium intake during bisphosphonate therapy is crucial.

Keywords:
BisphosphonatesHypocalcemiaOsteoporosis

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K
Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii
09:04

Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii

Published on: April 16, 2016

22.4K

Related Experiment Videos

Last Updated: May 3, 2026

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
05:14

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

3.7K
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.5K
Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii
09:04

Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii

Published on: April 16, 2016

22.4K

Area of Science:

  • Endocrinology
  • Nephrology
  • Geriatric Medicine

Background:

  • Bisphosphonates are commonly used to treat bone diseases.
  • While generally safe, bisphosphonates can induce hypocalcemia, a condition that can be asymptomatic or severe.
  • Severe hypocalcemia can lead to life-threatening complications if not recognized and managed promptly.

Observation:

  • A 78-year-old woman with a history of hip arthroplasty and recent intravenous zoledronate treatment presented with altered mental status.
  • Her symptoms were attributed to severe hypocalcemia secondary to zoledronate therapy, compounded by renal dysfunction.
  • The patient was successfully treated with intravenous calcium gluconate and calcitriol.

Findings:

  • Intravenous bisphosphonate therapy, such as zoledronate, poses a risk of severe hypocalcemia.
  • Renal dysfunction significantly increases the risk of bisphosphonate-induced hypocalcemia.
  • Prompt recognition and management with calcium and vitamin D analogs are effective treatments.

Implications:

  • Pre-treatment evaluation for renal dysfunction, vitamin D deficiency, and parathyroid health is essential before initiating bisphosphonate therapy.
  • Continuous monitoring of plasma calcium and creatinine levels is critical during bisphosphonate treatment.
  • Adequate calcium and vitamin D supplementation is mandatory for patients receiving bisphosphonates to prevent hypocalcemia.