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Clinical value of tapentadol extended-release in painful diabetic peripheral neuropathy

Bansri Desai1, Erin Freeman, Ellen Huang

  • 1University of Maryland School of Pharmacy, 300 West Lombard St, Apt 413, Baltimore, MD 21201, USA.

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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