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Angiotensin-(1-7): a peptide hormone with anti-cancer activity.

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Angiotensin-(1-7) [Ang-(1-7)], a peptide hormone, shows promise as a novel cancer therapeutic. Pre-clinical and clinical studies indicate it effectively reduces tumor growth, metastasis, and associated side effects.

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Area of Science:

  • Oncology
  • Pharmacology
  • Endocrinology

Background:

  • Peptides are increasingly utilized as therapeutic agents for various diseases.
  • The renin-angiotensin system includes angiotensin-(1-7) [Ang-(1-7)], a heptapeptide hormone with potential therapeutic applications.

Purpose of the Study:

  • To review pre-clinical and clinical data on the anti-cancer properties of Ang-(1-7).
  • To evaluate Ang-(1-7) as a potential peptide chemotherapeutic agent.

Main Methods:

  • Review of in vitro and in vivo studies in mouse models assessing Ang-(1-7)'s effect on cancer cells and tumors.
  • Analysis of data from three clinical trials investigating Ang-(1-7)'s safety, tolerability, and efficacy in cancer patients.

Main Results:

  • Ang-(1-7) reduced human cancer cell and xenograft tumor proliferation.
  • Observed decreases in angiogenesis, fibrosis, osteoclastogenesis, inflammation, and metastasis.
  • Clinical trials demonstrated good tolerability and clinical benefit in patients with solid tumors.

Conclusions:

  • Ang-(1-7) exhibits anti-cancer effects through multiple mechanisms, including targeting the tumor microenvironment.
  • Ang-(1-7) shows potential as a first-in-class peptide chemotherapeutic agent.
  • Further research into Ang-(1-7) for cancer therapy is warranted.