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Updated: Jan 26, 2026

In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells
Published on: April 25, 2019
Development course and an application strategy for induced pluripotent stem cells in regenerative medicine
Yuanzhi Xu, Jing Wang, Runyi Mao
1Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yanchang Road, Shanghai 200072, P.R. China. raoraowang@tongji.edu.cn.
Abstract:
In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
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