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Oral lichenoid tissue reactions: diagnosis and classification
Ahmed Salih Khudhur1, Giovanni Di Zenzo, Marco Carrozzo
1Oral Medicine Department, Centre for Oral Health Research, Newcastle University, Framlington Place, NE2 4BW, Newcastle upon Tyne, UK.
Expert Review of Molecular Diagnostics
|February 15, 2014
Summary
Oral lichenoid tissue reactions (OLTRs) encompass diverse inflammatory conditions affecting the oral mucosa. Molecular techniques may improve the diagnosis of these complex oral lesions when clinical and histological methods fall short.
Area of Science:
- Dermatology
- Oral Medicine
- Pathology
Background:
- Interface dermatitis, or lichenoid tissue reaction (LTR), describes inflammatory skin diseases with shared histopathological features.
- The oral mucosa can also present with various oral lichenoid tissue reactions (OLTRs), mimicking skin conditions.
- Diagnosing OLTRs traditionally relies on clinical and histological examination.
Purpose of the Study:
- To review the spectrum of oral lichenoid tissue reactions (OLTRs).
- To highlight the diagnostic challenges in differentiating various OLTRs.
- To explore the potential of molecular techniques in improving OLTR diagnosis.
Main Methods:
- Review of existing literature on oral lichenoid tissue reactions.
- Analysis of histopathological features common to OLTRs.
- Discussion of diagnostic criteria and limitations.
Main Results:
- Oral lichenoid tissue reactions (OLTRs) include a range of conditions such as oral lichen planus, drug reactions, and autoimmune diseases.
- Clinical and histological correlation is often insufficient for definitive diagnosis of OLTRs.
- Molecular techniques offer a promising avenue for more precise differentiation of OLTRs.
Conclusions:
- Accurate diagnosis of OLTRs is crucial for appropriate patient management.
- Current diagnostic methods for OLTRs have limitations.
- Integrating molecular diagnostics could significantly enhance the ability to distinguish between different oral lichenoid lesions.
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