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Updated: May 3, 2026
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Impaired white-matter integrity in photosensitive epilepsy: a DTI study using tract-based spatial statistics
Hanjian Du1, Bing Xie2, Peigang Lu1
1Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, China.
Background And Purpose:
The present study was designed to map alterations in brain white-matter in photosensitive epilepsy (PSE) by applying tract-based spatial statistics (TBSS) analysis.
Methods:
Diffusion tensor-imaging (DTI) data from MRI brain scans were collected from eight PSE patients and 16 gender- and age-matched non-epileptic controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI scans were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) values in the PSE and control groups were compared using TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement.
Results:
Compared with the control subjects, the corpus callosum of PSE patients had significantly lower FA values.
Conclusion:
Our DTI study indicates that white-matter in the corpus callosum was abnormal in PSE patients, and that DTI methods can serve as useful non-invasive tools to evaluate white-matter changes in PSE patients.
