[Effect of proteolytic inhibitors from human plasma on the activity of native and immobilized terrilytin]

Human blood plasma inhibitors are studied for their effect on the activity of terrilytin, a proteolytic enzyme of microbial origin, and terridecase, its immobilized form. The main plasma inhibitor of terrilytin is alpha 2-macroglobulin (alpha 2 MG). The pattern of terrilytin and terridecase interaction with alpha 2 MG preparation isolated from human blood plasma has also been studied. The inhibitor is found to exert a slight retarding effect on the terridecase activity. Significant differences in alpha 2 MG inactivation of terrilytin and trypsin are observed.