Related Experiment Video

Updated: May 3, 2026

Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
09:23

Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples

Published on: May 21, 2021

20.5K

An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis

Graham Devereux1, Sandra Steele2, Timothy Jagelman2

  • 1Section of Population Health, University of Aberdeen, Aberdeen AB25 2ZG, UK; Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|February 15, 2014
PubMed
Abstract

Insights

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in cystic fibrosis (CF) patients show associations with lung function decline and mortality, respectively. Further research is warranted for their use as prognostic biomarkers.

Area of Science:

  • Biochemistry
  • Pulmonology
  • Biomarkers

Background:

  • Previous studies indicate elevated sputum matrix metalloproteinase-9 (MMP-9) in cystic fibrosis (CF), negatively correlating with FEV1.
  • This study investigates the longitudinal association of MMP-9 and tissue inhibitors of metalloproteinases (TIMPs) with prognostic parameters in CF.

Purpose of the Study:

  • To examine the longitudinal association between MMP-9 and TIMPs with prognostic parameters in CF patients.
  • To explore MMP-9 and TIMP-1 as potential biomarkers for FEV1 decline and mortality in CF.

Main Methods:

  • Longitudinal follow-up of CF patients (median 49 months) and a cross-sectional control group.
  • Quantification of MMP-9, TIMP-1, and TIMP-2 in sputum and plasma samples.

Main Results:

  • Plasma MMP-9 activity was inversely associated with FEV1 and the rate of FEV1 decline in CF subjects.
  • Plasma TIMP-1 showed an adverse association with mortality in CF patients (HR 3.66, p < 0.001).

Conclusions:

  • MMP-9 and TIMP-1 warrant further investigation as biomarkers for predicting short- to medium-term FEV1 decline and mortality in CF.
  • These findings support the clinical relevance of MMP-9 and TIMP-1 in CF patient prognosis.
Keywords:
Cystic fibrosisFEV(1)MMP-9MortalityTIMP-1

More Related Videos

Detection of Functional Matrix Metalloproteinases by Zymography09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.6K
Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression08:58

Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression

Published on: April 18, 2025

1.1K

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.9K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
657