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Related Experiment Video

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Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
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Fibroblast growth factor-23 and cardiac structure and function.

Isha Agarwal1, Noriko Ide, Joachim H Ix

  • 1Department of Epidemiology, Harvard School of Public Health, Boston, MA.

Journal of the American Heart Association
|February 15, 2014
PubMed
Summary

Fibroblast growth factor-23 (FGF-23) did not significantly impact heart structure in individuals without severe chronic kidney disease. Its effects on cardiac function may depend on the klotho coreceptor.

Keywords:
chronic kidney diseasehypertrophystructure

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Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Fibroblast growth factor-23 (FGF-23) is linked to left ventricular hypertrophy and systolic dysfunction in chronic kidney disease (CKD).
  • The direct role of FGF-23 in inducing left ventricular hypertrophy, independent of its klotho coreceptor, remains unclear.

Purpose of the Study:

  • To investigate the association of FGF-23 with cardiac structural abnormalities across a spectrum of kidney function.
  • To explore potential biological mechanisms of FGF-23's cardiac effects using klotho-null mice.

Main Methods:

  • Cardiac magnetic resonance imaging and histology were used in klotho-null mice.
  • Associations of FGF-23 with cardiac structure and function were analyzed in 887 participants with coronary artery disease and varying kidney function.

Main Results:

  • FGF-23 showed a modest association with reduced left ventricular ejection fraction but not overall hypertrophy prevalence in the general cohort.
  • FGF-23 was associated with concentric hypertrophy only in individuals with impaired kidney function (eGFR <60 mL/min/1.73 m²).
  • Klotho-null mice did not exhibit increased left ventricular mass or reduced ejection fraction compared to wild-type mice.

Conclusions:

  • FGF-23 is unlikely to exert major cardiovascular effects in individuals without significant CKD.
  • Observed cardiovascular effects of FGF-23 may be dependent on the klotho coreceptor.