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Related Experiment Videos

Ocular response to hydrogen peroxide.

J R Paugh1, N A Brennan, N Efron

  • 1Southern California College of Optometry, Fullerton.

American Journal of Optometry and Physiological Optics
|February 1, 1988
PubMed
Summary
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This study found that higher hydrogen peroxide levels in contact lenses caused more discomfort and eye redness. Residual hydrogen peroxide in contact lens solutions should not exceed 100 ppm to ensure eye safety.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Toxicology

Background:

  • Hydrogen peroxide is a common disinfectant in contact lens care systems.
  • Understanding the ocular toxicity threshold of residual hydrogen peroxide is crucial for contact lens safety.
  • High water content hydrogel lenses may influence the ocular response to disinfectants.

Purpose of the Study:

  • To determine the ocular toxicity threshold of hydrogen peroxide delivered via hydrogel contact lenses.
  • To assess the relationship between hydrogen peroxide concentration and ocular responses.
  • To establish safe residual hydrogen peroxide levels for contact lens wear.

Main Methods:

  • A controlled, randomized, double-masked study involving eight human subjects.
  • Assessed subjective comfort, conjunctival hyperemia, and corneal/conjunctival staining.

Related Experiment Videos

  • Measured corneal oxygen uptake after 5-minute wear of lenses soaked in varying hydrogen peroxide concentrations (0-800 ppm).

    • Main Results:

    • Increased hydrogen peroxide concentrations correlated with greater subjective discomfort (p<0.05) and conjunctival hyperemia (p<0.001).
    • No significant corneal or conjunctival epithelial staining was observed even at the highest concentration (800 ppm).
    • Corneal aerobic response remained unaltered across all tested hydrogen peroxide levels.

    Conclusions:

    • Residual hydrogen peroxide concentrations in contact lens care systems should be limited to 100 ppm.
    • These findings provide data for practitioners to estimate patient exposure to residual hydrogen peroxide.
    • The study supports the safety of current hydrogel contact lens technology within established disinfection protocols.