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Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear

Jason J Workman1, Hongfeng Chen1, R Nicholas Laribee1

  • 1Department of Pathology and Laboratory Medicine and Center for Cancer Research; University of Tennessee Health Science Center; Memphis, TN USA.

Cell Cycle (Georgetown, Tex.)
|February 15, 2014
PubMed

Insights

Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth. Recent findings reveal nuclear mTORC1 signaling

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Mechanistic target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth and proliferation.
  • mTORC1's cytoplasmic functions in translation regulation are well-established.
  • Emerging evidence points to novel nuclear roles for mTORC1 signaling.

Purpose of the Study:

  • To review recent findings on nuclear-specific mTORC1 signaling.
  • To discuss the implications of these nuclear roles in health and disease.

Main Methods:

  • Literature review of recent studies on mTORC1.
  • Analysis of research on nuclear-specific mTORC1 functions.
  • Synthesis of findings related to rDNA and RP gene transcription, cell cycle control, and epigenetics.

Main Results:

  • Nuclear mTORC1 signaling is involved in ribosomal DNA (rDNA) and ribosomal protein (RP) gene transcription.
  • mTORC1 plays a role in mitotic cell cycle control within the nucleus.
  • Nuclear mTORC1 influences epigenetic processes.

Conclusions:

  • Nuclear mTORC1 signaling represents a newly identified area of mTORC1 research.
  • Dysregulation of nuclear mTORC1 has potential relevance in various diseases.
  • Further investigation into nuclear mTORC1 functions is warranted.
Keywords:
acetylationcancerepigeneticshistonestarget of rapamycintranscription

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